A my* self-medicated with cocaine and alcohol for 26 years while holding down a high-pressure job before she had a self-described breakdown at age 42. After mental health treatment at a private clinic, and subsequent sobriety, she was surprised to find herself 鈥榲ery dysregulated鈥 when she returned to work. The roots of her addiction 鈥 undiagnosed ADHD and autism 鈥 had been completely missed in the clinic. 鈥楥ocaine and amphetamine-based drugs can actually help a person with ADHD calm down and focus. Once I got clean, my self-medication had effectively been taken away, enhancing my ADHD traits,鈥 says Amy.
鈥楾he psychiatrist who eventually diagnosed me believed I had remained undiagnosed for so long because I had found cocaine at an early age; I was also self-medicating to stop feeling so out of place. I only wish more treatment and rehab centres factored in screening to help identify neurodivergent residents at intake.'
Despite increasing numbers of individuals identifying as neurodivergent, there is still a surprising lack of awareness of the links between addiction, autism and coexisting ADHD 鈥 with potentially deadly consequences. Neurodivergent author and trainer David Gray-Hammond calls addiction the 鈥榮ilent killer鈥 of the autistic and neurodivergent community. 鈥楶eople with ADHD may die because of their drinking,鈥 he said in a powerful blog, 鈥楰illing them softly鈥.1
Dr Mathias Luderer, a postdoctoral researcher at the University Hospital Frankfurt and Head of Addiction Services, agrees with Gray-Hammond鈥檚 stark premise of addiction catastrophically afflicting neurodivergent people. 鈥業n my patient group who have addiction and also ADHD, almost none of them received an ADHD diagnosis before they found themselves requiring help for their addiction. So if Gray-Hammond鈥檚 reference to 鈥渟ilent killer鈥 means people with ADHD die because of their substance abuse without getting diagnosis and treatment, I agree,鈥 he says.
Statistics also show autistic people are still more likely to die by suicide than the general population.2,3 鈥楳any neurodivergent clients who overdose and self-injure have unhealthy relationships with drugs and/or alcohol,鈥 says Alice McCarron, a neurodivergent clinical practice lead for an NHS self-injury service. 鈥楶otential causative factors for suicidality in autistic individuals include coexisting mental health problems, late diagnosis, adverse life events, masking one鈥檚 true self in order to fit in, and sensory processing differences,鈥 she says.
The number of undiagnosed neurodivergent individuals in addiction is still unknown, but we do know there were 275,896 adults in contact with drug and alcohol services between April 2020 and March 2021.4 Given it is estimated that around one per cent of the population is autistic, and that 6.5% of the population has ADHD,5 we could estimate that 2,700 autistic individuals and just under 18,000 people with ADHD may be represented in the population served by drug and alcohol services.
Substance use-related problems have been observed in 19-30% of diagnosed autistic individuals in clinical settings. A landmark population-based study documented a doubled risk of alcohol and substance use-related problems among autistic adults when compared to the general population, and a further increased risk when autism co-occurs with ADHD.6 There鈥檚 said to be 鈥榮ignificant genetic overlap鈥 with ADHD and alcohol use disorders (AUDs) 鈥 researchers have identified 鈥榝requent association鈥 between alcohol dependence and ADHD7 and pinpointed hyperactivity as a relevant symptom in ADHD and AUDs.8
Of course, these figures do not take into account that many neurodivergent people 鈥 potentially representing a sizeable chunk of addiction counsellors鈥 caseloads, as well as a number of those seeking therapy from non-specialist counsellors 鈥 may be unaware they are autistic or have ADHD, or that the demands of fitting into a neurotypical world are major drivers to self-medicate with substances and alcohol. For these reasons, it could be argued that every practitioner needs to be aware of the potential links between neurodivergence and substance abuse.
Next in this issue
Hypotheses
There are several theories linking neurodivergence and addiction 鈥 an extremely simplified hypothesis is that people with ADHD have underactivity of dopamine in their brains. Dopamine characteristics are associated with reward valuation9 and people with ADHD can require higher levels of external stimulation and novelty to activate reward systems.10 As anticipation and consumption of reward are factors in addiction, individuals with dopamine dysfunction are potentially more at risk.11 Meanwhile, anxiety and sensory overreactivity may drive the coping mechanisms of autistic individuals who experience substance misuse.
A recent scientific review found 鈥榮ignificant genetic overlap鈥 with ADHD and AUDs:13 鈥楢DHD drives negative experiences that enhance a genetically-increased risk for AUDs. As impulsive decisions and a maladaptive reward system make individuals with ADHD vulnerable for alcohol use, up to 43% develop an alcohol use disorder.鈥
The presence of untreated ADHD has been shown to negatively influence treatment outcomes for substance use disorder.12 鈥楶sychotherapy, especially in a group setting, is hard for someone with ADHD who is not on medication; treatment dropout is much more likely when ADHD is not treated,鈥 says Luderer, the author of the study.
According to Luderer, patients with ADHD and addiction rarely ask for diagnostic assessment. 鈥楾hey live with their brain and behaviour for their whole life. Even though ADHD is common in people with addiction, it is often overlooked by addiction professionals if routine screening is not carried out. Identification of ADHD in this client group can improve the probability of the patients benefitting from psychotherapy treatment 鈥 stimulant treatment helps them to focus on psychotherapy and reduces impulsivity and emotional dysregulation.鈥
Autism and addiction
It is thought that anxiety plays a big part in addiction in autistic individuals. Both formal studies and the lived experiences of autistic people tell us anxiety is coexistent to autism.14 It is also thought that the atypical structure of the brain鈥檚 amygdala (the region involved in emotions) seen in some studies of autistic individuals closely relates to anxiety.15 We know that the sensory overreactivity that autistic people are prone to also exacerbates anxiety.16 When sights, sounds and textures can feel overwhelming, it is natural that anxiety and overwhelm ensue. A recent study linked anxiety with atypical amygdala volume in autistic individuals; such individuals may be hypervigilant to the brain鈥檚 threat response.17,18
Furthermore, growing evidence implicates the importance of healthy amygdala function in the mediation of the so-called stress-dampening properties of alcohol. Early studies, for example, proposed that faulty amygdala function can predispose individuals to both anxiety and alcoholism, finding excessive alcohol-drinking behaviour can mediate anxiety.19 It therefore makes sense that autistic individuals, already predisposed to anxiety due to sensory processing differences, may use substances to reduce anxious responses.
Diane Evans* is a neurotypical counsellor specialising in working with neurodivergent clients. She also volunteers as a counsellor at a residential alcohol and drug addiction rehabilitation centre. Evans is aware that very few clients in treatment for addiction at the rehab centre have a diagnosis of autism, despite this neurotype being overrepresented in percentage terms within addiction services as a whole, when compared with the wider percentage of adults using addiction services.
She agrees that anxiety is seemingly a major contributing factor for some neurodivergent clients facing addiction. 鈥業n clients who have a diagnosis, or may self-identify as neurodivergent, it is common to hear they have used substances to consciously manage their symptoms of anxiety. I also see a lot of trauma-type responses in this client group. In the few clients I see with diagnosed ADHD, it is not uncommon to hear that substances such as cocaine, cannabis, ketamine or alcohol have been used as a coping mechanism, especially in social settings,鈥 says Evans.
Social difficulties
Faye Lewis,* a neurodivergent art psychotherapist working within both young people鈥檚 support services and adult addiction, says social anxiety can be a causative factor for autistic individuals self-medicating with alcohol and substances. Lewis has experienced substance and alcohol misuse herself. 鈥楤eing autistic and having ADHD played a big part in my personal experience of substance misuse 鈥 social difficulties, fluctuating moods, anxiety and depression, internalising shame, impulsivity, not talking about my problems, masking and subsequent exhaustion,鈥 she says Now sober, Lewis believes she had a psychological reliance on substance misuse, rather than physical dependence on drugs or alcohol. Her association with substance misuse began from a deep sense of loneliness around not fitting in with secondary school peers, teamed with the opportunity to drink, she says. 鈥楾he combination of attachment difficulties, needing to feel validated through others, trauma through peer rejection, and being undiagnosed as autistic meant that when alcohol was present I would drink it,鈥 says Lewis.
鈥業t鈥檚 essential that as a profession, we reframe our perspective on what addictive behaviours actually mean,鈥 she says. 鈥楩or example, some behaviours seen in neurodivergent clients can come across as 鈥渁voidant鈥 or 鈥渃hallenging鈥 to a therapist, when in fact they鈥檙e a different way of processing things. An understanding of a client鈥檚 potential neurodivergence could change everything regarding how their experience of addiction is explored in therapy.鈥
Misdiagnosis
Marina McAdam is an autistic US-based addiction counsellor, recovery coach and adjunct professor of education specialising in neurodivergence. Some of the barriers she has noticed working specifically in an addiction treatment setting include a lack of understanding of the tailored support needed for neurodivergent people. 鈥楩or example, undergoing therapy in large groups, such as 12-step programmes, may be anxiety-producing for clients and lead to more addictive behaviours as a coping mechanism for the anxiety,鈥 she says.
Many of her neurodivergent clients have experienced misdiagnosis, says McAdam. 鈥楴ot being diagnosed correctly, they have no access to treatments and medications that can help them with everyday functioning, potentially affecting employment,鈥 she says. 鈥楢 lack of accommodations and knowledge from employers potentially lead to work termination. These negative experiences of being undiagnosed or misdiagnosed, possibly with comorbid conditions as well, in conjunction with not being accepted for who they are, being criticised and judged, and lacking the ability to lead a financially independent life, may cause enormous trauma that leads to addiction. It is not helped by the fact that many therapists whom my clients have seen previously are not trained in neurodivergent issues and presentations.鈥
Evans agrees that misdiagnosis is a problem for neurodivergent clients and typically exacerbates their distress. 鈥業 have noticed that some neurodivergent clients have been through many assessment processes with mental health services, often receiving multiple diagnoses, including a personality disorder or bipolar disorder, before they finally see a practitioner who introduces the possibility of neurodivergence, which most immediately identify with and feel describes their difficulties,鈥 Evans says.
Accessibility
In terms of what we as therapists can do to make addiction-specific therapy accessible to neurodivergent clients, McCarron says this client group may need extra accommodations. 鈥楩or example, they may benefit from more specific instructions on where to go in a new counselling or therapy space, such as visual images of the area, and details on how the group runs. Where possible, it is a good idea to offer a buddy to go with them. Also, we can offer accommodations such as allowing neurodivergent clients more time to settle in before having to share their 鈥渓ife story鈥 in a group setting,鈥 she says.
Some neurodivergent clients need more space to process their thoughts before they feel confident to answer questions, she says: 鈥楻ound robin exercises are the 鈥楽ocial anxiety can be a causative factor for autistic individuals self-medicating with alcohol and substances鈥 the job of a counsellor to diagnose a client鈥檚 neurodivergence, but signposting can definitely support an undiagnosed neurodivergent client in their counselling journey,鈥 says Evans. 鈥楢t the rehab facility where I volunteer there have been many clients whom I have suspected may have an undiagnosed neurodivergent condition. My role is to use my knowledge and experience to support a client to seek a formal assessment, if the indications are they may be neurodivergent, and if they feel an assessment may be helpful.鈥 For counsellors and psychotherapists working in addiction services, educating ourselves about the undeniable links between addiction and neurodivergence is key. Signposting a client to suitable services could positively affect their recovery journey, and even save a life. *Names and identifiable details have been changed worst for this 鈥 feeling put on the spot does not help with being able to think, it just immediately puts you in the 鈥渁mygdala hijack zone鈥. Some neurodivergent clients may for example blurt something out without thinking, but we need to reframe from this being a dysfunctional behaviour to one that鈥檚 part of their neurodivergence, and help the client understand it.鈥
Evans agrees we must do better in acknowledging that human brains work in different ways. 鈥業n my experience, the demands of a residential setting combined with groupwork can be immense barriers to neurodivergent clients succeeding in rehab,鈥 she says. 鈥業ssues such as noise sensitivity, the unpredictability of engaging with a large group of new people, alexithymia (difficulty recognising emotions), the overwhelm of an unfamiliar routine, together with expectations of exploring feelings in a group, can often lead to an early exit from rehab. Also, for an autistic individual in rehab who needs quiet time alone to cope with overwhelm, the encouragement to engage with a group and not self-isolate can be counterproductive to their wellbeing.鈥
In individual therapy, neurodivergent people often cite feeling very comfortable undergoing video-based counselling. A recent scientific review on 鈥榗yber health psychology鈥 and addiction found mobile health has many 鈥榖enefits and advantages鈥 for therapist and client, typically when utilised with a 鈥榩arallel psychotherapy path鈥.20
McAdam says online therapy can be significantly less stress-inducing for socially anxious clients. 鈥楩or example, navigating the journey to an unfamiliar counselling room and the avoidance of excessive socialisation in reception areas and on public transport. Individuals and organisations offering addiction counselling or therapy are encouraged to offer telehealth-based provisions for neurodivergent clients where possible,鈥 she says
Signposting
The issue of whether counsellors should flag up the potential for neurodivergence to a client they suspect is autistic, or has ADHD, remains complex. 鈥業t is ethically not the job of a counsellor to diagnose a client鈥檚 neurodivergence, but signposting can definitely support an undiagnosed neurodivergent client in their counselling journey,鈥 says Evans. 鈥楢t the rehab facility where I volunteer there have been many clients whom I have suspected may have an undiagnosed neurodivergent condition. My role is to use my knowledge and experience to support a client to seek a formal assessment, if the indications are they may be neurodivergent, and if they feel an assessment may be helpful.鈥
For counsellors and psychotherapists working in addiction services, educating ourselves about the undeniable links between addiction and neurodivergence is key. Signposting a client to suitable services could positively affect their recovery journey, and even save a life.
*Names and identifiable details have been changed
References
1. Gray-Hammond D. Killing them softly: addiction is the silent killer of the autistic and neurodivergent community. [Blog.] NeuroClastic 2020; 1 March. (Accessed 11 September 2023.) bit.ly/3sTWEWi
2. Cassidy S. Suicidality and self-harm in autism spectrum conditions. In: White S, Maddox B, Mazefsky C (eds). Oxford handbook of autism and co-occurring psychiatric conditions. Oxford: Oxford University Press; 2020.
3. Cassidy S et al. Autism and autistic traits in those who died by suicide in England. The British Journal of Psychiatry 2022; 1鈥9.
4. Gov.uk. Adult substance misuse treatment statistics 2020 to 2021: report. Office for Health Improvement & Disparities 2021; 25 November. bit.ly/45NwZ06
5. New landmark strategy to improve the lives of autistic people (press release). [Online.] Department of Health and Social Care 2021; 21 July. (Accessed 11 September 2023.) bit.ly/465Lkox
6. Butwicka A et al. Increased risk for substance use-related problems in autism spectrum disorders: a population-based cohort study. Journal of Autism and Developmental Disorders 2017; 47(1): 80-89.
7. Kapit谩ny-F枚v茅ny M et al. Recommendations for the screening, diagnosis and treatment of patients with comorbid attention deficit hyperactivity- and substance use disorder. Psychiatria Hungarica: A Magyar Pszichiatriai Tarsasag Tudomanyos Folyoirata 2020; 35(4): 435-447. bit.ly/3P9BE5D
8. Luderer M et al. Drinking alcohol to cope with hyperactive ADHD? Self-reports vs. continuous performance test in patients with ADHD and/or alcohol use disorder. Frontiers in Psychiatry 2023; 14:1112843.
9. Dang LC et al. Individual differences in dopamine D2 receptor availability correlate with reward valuation. Cognitive, Affective, & Behavioral Neuroscience 2018; 18 (4): 739鈥747.
10. Volkow ND. Imaging dopamine鈥檚 role in drug abuse and addiction. Neuropharmacology 2009; 56(1): 3鈥8.
11. Johnson J et al. Managing comorbid attention deficit hyperactivity disorder (ADHD) in adults with substance use disorder (SUD): what the addiction specialist needs to know. Addictive Disorders & Their Treatment 2020; 20(3): 181-188.
12. Carpentier PJ et al. Pharmacological treatment of ADHD in addicted patients. Harvard Review of Psychiatry 2017; 25(2): 50鈥64.
13. Luderer M et al. Alcohol use disorders and ADHD. Neuroscience and Biobehavioral Reviews 2021; 128: 648鈥660.
14. Kast K et al. Pharmacotherapy for attention-deficit/ hyperactivity disorder and retention in outpatient substance use disorder treatment: a retrospective cohort study. Journal of Clinical Psychiatry 2021; 82(2).
15. Hennessy A et al. Anxiety in children and youth with autism spectrum disorder and the association with amygdala subnuclei structure. Autism 2023; 27(4): 1053鈥1067.
16. Gara SK et al. The sensory abnormalities and neuropsychopathology of autism and anxiety. Cureus 2020; 12(5): e8071.
17. Andrews DS et al. Association of amygdala development with different forms of anxiety in autism spectrum disorder. Biological Psychiatry 2022; 91(11), 977鈥987.
18. Amaral DG, Corbett BA. The amygdala, autism and anxiety. In: Bock G, Goode J (eds). Autism: neural basis and treatment possibilities. London: Wiley; 2003 (pp177鈥197).
19. Wand G. The anxious amygdala: CREB signaling and predisposition to anxiety and alcoholism. Journal of Clinical Investigation 2005; 115(10): 2697鈥2699.
20. Caponnetto P, Casu M. Update on cyber health psychology: virtual reality and mobile health tools in psychotherapy, clinical rehabilitation, and addiction treatment. International Journal of Environmental Research and Public Health 2022; 19(6): 3516.